Lorca Lab Publications

Clinical Trial

• Lactobacillus johnsonii N6.2 Modulates the Host Immune Responses: A Double-Blind, Randomized Trial in Healthy Adults (2017)

Animal Studies

• Lactobacillus johnsonii N6.2 Mitigates the Development of Type 1 Diabetes in BB-DP Rats (2010)
• Lactobacillus johnsonii N6.2 Stimulates the Innate Immune Response through Toll-Like Receptor 9 in Caco-2 Cells and Increases Intestinal Crypt Paneth Cell Number in BioBreeding Diabetes-Prone Rats (2011)
• Sex Modulates Lactobacillus johnsonii N6.2 and Phytophenol Effectiveness in Reducing High Fat Diet Induced MTOR Activation in Sprague-Dawley Rats (2018)
• Lactobacillus johnsonii N6.2 Diminishes Caspase-1 Maturation in the Gastrointestinal System of Diabetes Prone Rats (2018)
• Lactobacillus johnsonii N6.2 and Blueberry Phytophenols Affect Lipidome and Gut Microbiota Composition of Rats Under High-Fat Diet (2021)
• Inhibition of Type 1 Diabetes Correlated to a Lactobacillus johnsonii N6.2-Mediated Th17 Bias (2011)

Further Studies

• Nanovesicles From Lactobacillus johnsonii N6.2 Reduce Apoptosis in Human Beta Cells by Promoting AHR Translocation and IL10 Secretion (2022)
• Internalization of extracellular vesicles from Lactobacillus johnsonii N6.2 elicit an RNA sensory response in human pancreatic cell lines (2023)
• Lactobacillus johnsonii N6.2 phospholipids induce immature-like dendritic cells with a migratory-regulatory-like transcriptional
• Identification of Biomarkers for Systemic Distribution of Nanovesicles From Lactobacillus johnsonii N6.2 (2021)
• Complete Genome Sequences of Lactobacillus johnsonii Strain N6.2 and Lactobacillus Reuteri Strain TD1 (2014)
• Biochemical Properties of Two Cinnamoyl Esterases Purified from a Lactobacillus johnsonii Strain Isolated from Stool Samples of Diabetes-Resistant Rats (2009)
• H2O2 Production Rate in Lactobacillus johnsonii Is Modulated via the Interplay of a Heterodimeric Flavin Oxidoreductase with a Soluble 28 Kd PAS Domain Containing Protein (2015)