Description of Research
General area: The Edelmann Lab is investigating the novel host-directed therapies against Gram-negative infections and the functions of exosomes and other extracellular vesicles in enteric infections. We also have an interest in improving the delivery methods for therapeutic strategies, such as enzyme replacement therapies.
Our group predominantly studies molecular aspects of the immune responses in Salmonella enterica Typhimurium and Yersinia ssp. infections. For instance, we discovered a novel function of exosomes in priming the innate and adaptive immune responses against Salmonella infection and we are currently investigating the roles of exosomes in detail.
We also identified new roles of bioactive lipids such as prostaglandins in the macrophage polarization, which is important in the elimination of bacteria. We also found that bacterial pathogens perturb the prostaglandin system by their virulence factors. Currently, we are interested in the function of other bioactive lipids, such as endocannabinoids, and cannabinoids in the host response to infection and the regulation of inflammation.
Finally, we specialize in multi-omics techniques and tools such as chemical proteomics to characterize the host-pathogen interactions, post-translational modification, and other aspects of cellular biology.
- Teaching Interests
- MCB 6937 - Post-Translational Modifications in Microbiology
- MCB 5205 - Microbiology of Human Pathogens
- MCB 4203 - Bacterial Pathogens